low serum levels of 25-hydroxyvitamin d in association with type 2 diabetes in indian patients
نویسندگان
چکیده
objective: vitamin d deficiency is a common disorder worldwide and is indicated by low serum 25-hydroxyvitamin d levels. recent studies have suggested an association of 25-hydroxyvitamin d deficiency with diabetes mellitus. the objective of this study is to investigate the relationship between 25-hydroxyvitamin d concentration and type 2 diabetes in south indian patients. materials and methods: in a cross sectional study, we recruited 150 patients with type 2 diabetes and 150 age and sex matched controls, yashoda hospital, hyderabad, india, from december 2011 to november 2013. all cases and controls were evaluated for fasting serum glucose, fasting insulin, serum cholesterol, calcium, phosphorus, alkaline phosphatase, c-reactive protein (crp), glycosylated hemoglobin (hba1c) and 25-hydroxyvitamin d levels. results: in both 150 cases and 150 controls, mean age was 51.5 years and 70% participants were men. deficiency of 25-hydroxyvitamin d (42.6%) (p<0.0001) and crp positivity (48%) (p<0.0001) were significantly more common and mean alkaline phosphatase (143±3.4) (p<0.0001), mean hba1c (8.3±1.8) (p<0.0001) and mean homa ir (3.80 +1.45) (p<0.0001) were higher in cases compared to controls. in type 2 diabetes, 25-hydroxyvitamin d deficiency was significantly associated with elevated longer mean duration of diabetes 15.1±4.3 years (p<0.0001), positive crp (0.02), increased homa –ir (<0.0001), neuropathy 19 (29.6%) (p=0.03), and retinopathy 11(15.6%) (p=0.04).after adjustment using multiple logistic regression analysis, deficiency of 25-hydroxyvitamin d was independently associated with type 2 diabetes (odds: 2.8 95% ci: 1.80 - 8.09). conclusion: our study showed a 42.6% prevalence of 25-hydroxyvitamin d deficiency in type 2 diabetes and was independently associated with type 2 diabetes in indian adults.
منابع مشابه
Low Serum Levels of 25-Hydroxyvitamin D in Association with Type 2 Diabetes in Indian Patients
Objective: Vitamin D deficiency is a common disorder worldwide and is indicated by low serum 25-hydroxyvitamin D levels. Recent studies have suggested an association of 25-hydroxyvitamin D deficiency with diabetes mellitus. The objective of this study is to investigate the relationship between 25-hydroxyvitamin D concentration and type 2 diabetes in South Indian patients. Materials and Methods...
متن کاملAssociation between Serum 25-hydroxyvitamin D Levels and Type 2 Diabetes in Korean Adults
Previous studies have suggested that a vitamin D deficiency increases the risk of type 2 diabetes. This study evaluated the association between serum vitamin D levels and type 2 diabetes in Korean adults. This study included 9,014 subjects (3,600 males and 5,414 females) aged ≥50 years who participated in the Dong-gu Study. The subjects were divided into groups in whom the serum vitamin D level...
متن کاملLow Serum 25‑hydroxyvitamin D levels: Predictive Value of Hematological and Inflammatory Markers in Patients with Urinary Tract Infection
Background: Low vitamin D has been linked to enhance inflammatory markers in various pathological conditions. We aimed to evaluate the urinary tract infection (UTI)-associated hematological and inflammatory markers mediated by low serum levels of 25-hydroxyvitamin D [25(OH)D]. Methods: Vitamin D level, hematological indices (Neutrophil-to-lymphocyte ratio [NLR], Monocyte-to-lymphocyte ratio [M...
متن کاملAssociation between serum 25‐hydroxyvitamin D and glycated hemoglobin levels in type 2 diabetes patients with chronic kidney disease
AIMS/INTRODUCTION Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D (25[OH]D) and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes was reported. We aimed to examine this association among type 2 diabetes patients with CKD. MATERIALS AND METHODS A total of 100 type 2 diabetes participants with st...
متن کاملLow serum 25-hydroxyvitamin D levels and the bidirectional association between depression and type 2 diabetes mellitus in women.
BACKGROUND Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting. METHODS A total of 65 381 women aged 50 to 75 years in 1996 were observed until 2006. Clinical depression was defined as having diagnosed depression or using antidepressants, and depressed mood was defined as having clinical ...
متن کاملSerum 25-hydroxyvitamin D levels in patients with Granulomatosis with Polyangiitis: association with respiratory infection
OBJECTIVES To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn. METHODS Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5) were evaluated ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of diabetes and obesityجلد ۶، شماره ۲، صفحات ۴۷-۵۵
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023